BIOMARKERS OF OXIDATIVE STRESS IN THE MUSCLE TISSUE OF RAINBOW TROUT (ONCORHYNCHUS MYKISS WALBAUM) AFTER IN VITRO TREATMENT BY EXTRACTS DERIVED FROM STALKS AND ROOTS OF GREATER CELANDINE (CHELIDONIUM MAJUS L.)

Consistent with our previous studies, we continue to evaluate the antioxidant potential of Greater celandine (Chelidonium majus L), a representative Papaveraceae family, collected from northern Poland using model muscle tissue rainbow trout (Oncorhynchus mykiss Walbaum). Therefore, in present study, oxidative stress biomarkers [2-thiobarbituric acid reactive substances (TBARS), protein modification carbonyl derivative content, total capacity (TAC)] were used activity extracts (final concentration 5 mg/mL) derived stems and roots C. majus. Rainbow was this study. Phosphate buffer as positive control (blank). The results current study showed that stem root exhibited cytotoxic effects on cellular structures by increasing level lipid peroxidation biomarkers. These suggest possibility extract at mg/mL source pro-oxidant compounds warrant further studies their therapeutic potential. Levels aldehydic ketonic derivatives oxidatively modified proteins not significantly changed after vitro incubation stalks Screening species family for other biological activities, including activity, is essential may be effective search preventive measures pathogenesis some diseases, well prevention treatment disorders medicine veterinary.